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Study ties fertility treatment, birth defect risk

Test-tube babies have higher rates of birth defects, and doctors have long wondered: Is it because of certain fertility treatments or infertility itself? A large new study from Australia suggests both may play a role.

Compared to those conceived naturally, babies that resulted from simple IVF, or in vitro fertilization ? mixing eggs and sperm in a lab dish ? had no greater risk of birth defects once factors such as the mom's age and smoking were taken into account.

However, birth defects were more common if treatment included injecting a single sperm into an egg, which is done in many cases these days, especially if male infertility is involved. About 10 percent of babies born this way had birth defects versus 6 percent of those conceived naturally, the study found.

It could be that the extra jostling of egg and sperm does damage. Or that other problems lurk in the genes of sperm so defective they must be forced to fertilize an egg.

"I don't want to scare people," because the vast majority of babies are born healthy, said the study's leader, Michael Davies of the University of Adelaide in Australia.

Couples could use simple IVF without sperm injection, freeze the embryos and implant only one or two at a time, he said. All of those can cut the chance of a birth defect.

The study was published online Saturday by the New England Journal of Medicine and presented at a fertility conference in Barcelona, Spain. Health agencies in Australia paid for the research.

More than 3.7 million babies are born each year through assisted reproduction. Methods include everything from drugs to coax the ovaries to make eggs to artificial insemination and IVF. Fertility treatments account for about 4 percent of births in Australia and as many as 8 percent of them in Denmark, where costs are widely covered, Davies said.

In the United States, more than 60,000 babies were born in 2009 from 146,000 IVF attempts. About three-quarters of them used ICSI, or intracytoplasmic sperm injection.

ICSI was developed because of male infertility. But half the time, it was not done for that reason but to improve the odds that at least some embryos will be created from an IVF attempt. Many clinics do it in all cases.

IVF costs around $10,000 to $12,000 per attempt and another $2,000 for sperm injection.

The study used records on nearly 303,000 babies conceived naturally and 6,163 conceived with help in Australia from 1986 through 2002, plus records on birth defects detected by age 5. Researchers counted heart, spinal or urinary tract defects, limb abnormalities and problems such as cleft palate or lip, but not minor defects unless they needed treatment or were disfiguring.

They looked at birth defect rates according to type of fertility treatment. They also had three comparison groups of women who conceived naturally, including some with some history of infertility or who previously needed help to get pregnant.

Among fertility treatments, only ICSI, the sperm injection, resulted in higher rates of birth defects once other factors that affect these odds were taken into account.

"They take a sperm that is probably not normal and force it to conceive," said Dr. Darine El-Chaar, an OB-GYN at Canada's University of Ottawa. She led a smaller previous study of this and called the new work impressive and "the study that needed to be done" to sort out the source of these risks.

In the study, frozen embryos were less likely to result in birth defects than fresh ones used soon after they were created. Defective ones may be less likely to survive freezing and thawing, so the fittest embryos result in pregnancies, Davies said.

Babies born to women with a history of infertility who ended up conceiving on their own, or who had natural pregnancies after assisted ones, also had higher rates of birth defects. That suggests that infertility itself is playing a role.

Dr. Glenn Schattman, president of the Society for Assisted Reproductive Technologies and a Cornell University fertility specialist, said it was reassuring that ordinary IVF is safe. If ICSI is chosen because male infertility is involved, "parents have to be aware that by having a child with their own genetic material, they might be increasing their risk" of a birth defect, he said.

Dr. Joe Leigh Simpson, a geneticist and research chief at the March of Dimes, said doctors should take this work seriously and discuss it with patients. He said techniques have improved over the last decade and ICSI may be safer now than when this study began.

Even with genetic testing for various diseases, "we always tell our patients that this doesn't guarantee a perfect baby," he said.

___

Online:

New England Journal: http://www.nejm.org

Infertility information: http://www.sart.org and http://www.asrm.org

Sperm injection explanation: http://bit.ly/Inb688

CDC on fertility treatments: http://www.cdc.gov/art/ARTReports.htm

___

Follow Marilynn Marchione at http://twitter.com/MMarchioneAP

Associated Press

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Uhc health insurance - HEALTH, BEAUTY & FITNESS

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Virginia profile rises in presidential contest

President Barack Obama speaks at a celebration of Cinco de Mayo in the Rose Garden of the White House in Washington, Thursday, May 3, 2012. (AP Photo/Carolyn Kaster)

President Barack Obama speaks at a celebration of Cinco de Mayo in the Rose Garden of the White House in Washington, Thursday, May 3, 2012. (AP Photo/Carolyn Kaster)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney, greets supporters during a campaign stop in Portsmouth, Va., on Thursday, May 3, 2012. (AP Photo/Virginian-Pilot,Ross Taylor)

President Barack Obama waves as he leaves a celebration of Cinco de Mayo in the Rose Garden of the White House in Washington, Thursday, May 3, 2012. Speaking at the reception, Obama blamed the failure of the Dream Act on a few Republicans in Congress. Cinco de Mayo celebrations at the White House have become annual features under recent presidents. (AP Photo/Carolyn Kaster)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney, left, is introduced by Rep. Michele Bachmann, R-Minn., at a campaign stop in Portsmouth, Va., Thursday, May 3, 2012. (AP Photo/Jae C. Hong)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney, center, and Rep. Michele Bachmann, R-Minn., left, listen as Virginia Gov. Bob McDonnell speaks at a campaign stop in Portsmouth, Va., Thursday, May 3, 2012. (AP Photo/Jae C. Hong)

PORTSMOUTH, Va. (AP) ? Move over Ohio and Florida. Virginia is becoming the hottest new battleground in this year's race for the White House.

Shifting demographics have President Barack Obama fighting for another win in this Southern state four years after he became the first Democratic presidential nominee to carry Virginia in more than four decades. Republican rival Mitt Romney is banking on buyers' remorse as he works to prove that Obama's unlikely 2008 victory was a fluke.

Six months before Election Day, both sides concede that Virginia is truly up for grabs. And the outcome here could have dramatic consequences ? for Romney especially.

"This may well be the state that decides who the next president is," Romney told supporters Thursday in coastal Portsmouth, Va. "You're going to hear it all, right here in Virginia."

Already, Romney allies and Obama's campaign are pouring money into television ads. And, by week's end, each candidate will have visited the state.

Romney spent two days campaigning here this week, his first Virginia trip since becoming his party's presumptive presidential nominee. Obama will be in the state on Friday and Saturday ?what his aides are calling his first formal day of campaigning ? before traveling to Ohio.

Four years ago, Obama executed a winning strategy by registering and turning out scores of minorities and young voters who long had sat on the political sidelines.

This year, Virginia ? perhaps more so than any other state ? will test whether he can cobble together a similar winning coalition amidst shifting demographics and despite a challenging economic environment.

Virginia has swung dramatically right in the years since the Democratic president took office ? so much so, that Romney aides suggest that the state has become a linchpin in their national path to victory.

"It's an important key in the overall map," Romney's political director, Rich Beeson, said.

Republican insiders go further, saying that it's hard to see Romney reaching the 270 electoral votes needed without the 13 that Virginia provides.

Indeed, an Obama win here could prove devastating for Romney, whose team understands the challenge of unseating a sitting president who has tremendous financial and organizational advantages. Already, Obama has established a comprehensive ground game in Virginia, with more than 13 offices spread across the state. Romney, who spent most of the year consumed by a bitter and expensive Republican primary, has yet to open one.

Beeson said Thursday that the Romney campaign would be "up and running" in Virginia in the "next week or two."

The Obama campaign argues that the stakes are higher here for Romney.

"We can win without Virginia, but we don't think we need to," said Obama campaign manager Jim Messina. "The truth is we have several pathways to get to 270 electoral votes."

Virginia's prominent role in the 2012 presidential election follows a decade of political and demographic changes that make this fall's outcome difficult to predict.

Although Democrats had not aggressively competed in a Virginia presidential contest for a generation, Obama carried the state by 6 percentage points over Republican John McCain in 2008, based on an outpouring of the state's high African American vote and heavy turnout in the metropolitan Washington area. Before Obama, no Democrat had won Virginia since Lyndon Johnson in 1964.

Republican George W. Bush had carried it easily, by 8 percentage points, in 2000 and 2004.

"Over the last 10 years, there has been a progression. It has gone from solidly red to trending blue to settling right in the middle. It's about the most-purple shade of purple you can find," said Democratic strategist Mo Elleithee.

Virginia has a high black-voter base. But the state is also home to a growing number of younger, well-educated voters flocking to northern Virginia, the region where Obama is credited with winning the state ? and that makes it competitive again in 2012.

Obama carried the metropolitan Washington area of northern Virginia by 260,000 votes, about the same margin as he carried the entire state. Obama is hoping again to turn out big numbers in burgeoning suburbs such as Fairfax, Loudoun and Prince William counties, to offset the rising GOP tide elsewhere, where Romney is hoping he will prevail.

The political battle has already begun on the state's airwaves.

While Romney has yet to buy any ads directly, the pro-Romney group, Restore Our Future, has spent $354,000 in Virginia on a television advertising campaign that began running statewide Thursday. The ad highlights Romney's role in helping to find his business partner's lost daughter.

The Obama campaign spent $270,000 for a new ad ? its third so far in Virginia ? that began running statewide this week and accuses Romney of sending jobs overseas during his business career, reminding voters that the former Massachusetts governor had a Swiss bank account.

Virginia-based Republican strategist Chris LaCivita suggests that Obama is likely worried about his chances in Virginia if he's already using attack ads. But like others here, he says it's too early to make any predictions.

"To assume Virginia is going to go Republican is a dangerous thing to do," he said.

Women's issues, especially the recent debate over birth-control coverage by health insurance, play a disproportionate role in the northern part of the state, with its bustling suburbs. The rural economy, social issues and military policy are a problem for Obama in the more traditionally conservative parts of Virginia, such as the southeast, in places like Hampton Roads, where Romney campaigned this week.

Obama's team says it expects disproportionate turnout among the state's black voters. However, neither campaign is expecting the same record turnout that helped elect Obama the nation's first African American president.

Romney is banking on Virginia's recent Republican momentum to continue.

Republican Gov. Bob McDonnell, who has endorsed Romney, won election in 2009. The following year, Virginia Republicans made gains in the U.S. House, and last year in the state legislature.

Romney aides are bracing for resistance in crucial northern Virginia to the candidate's proposed 10-percent cut in the federal workforce. Virginia, and especially northern Virginia, is home to the nation's highest concentration of federal workers.

Romney senior adviser Ed Gillespie, a former Virginia GOP chairman, joined Romney Thursday as he campaigned in Portsmouth, a port town with a significant industrial base and a large military presence. "This is going to be a hard-fought state," Gillespie said, dismissing polls that show Obama slightly ahead of his Republican challenger.

New polling, however, suggests that Obama is ahead of Romney. The Washington Post released results Thursday giving Obama a 7-point lead, 51 percent to 44 percent, among registered voters.

The winner in Virginia, however, could win a much larger prize.

"If Obama wins Virginia, I think he wins the election," said Elleithee, the Democratic strategist.

___

Associated Press writer Thomas Beaumont contributed to this report.

Associated Press

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Quinton ?Rampage? Jackson and the UFC: Can this relationship be saved?

Lately, Quinton Jackson has been complaining about how he doesn't want to be in the UFC any more, and it appears the feeling is mutual from the UFC. They have become the couple that everyone knows should break up. Inexplicably, they stay together and annoy everyone around them. It's time to break this down, women's magazine style.

Cagewriter asks, can this relationship be saved?

Jackson says:

"After I leave the UFC, I'm done with them! ... The UFC's just throwing me all these boring fighters, these game planners, these wrestlers. I'm the type of fighter who you should match up with people who want to fight excitingly. You know what I'm saying? Cuz I'm gonna be the type of fighter who puts butts in seats."

UFC president Dana White says:

"I'll have a conversation with 'Rampage' and think we're cool, and then I'll read other stuff," he said. "We've been good to everybody we've ever dealt with. We've never screwed anybody over, including 'Rampage.' And you want to talk about a guy that we went to bat for ? we've gone to bat for him many times. I feel like [expletive] (Derek) Jeter when it comes to 'Rampage.' If he's unhappy with us, doesn't like us and doesn't want to be with us anymore, then the feeling is mutual."

Cagewriter responds, NO. This relationship cannot be saved. Jackson is miserable and will not be quiet until he is free from the UFC, so UFC? Let him go. Give him a quick fight to finish out his contract, or just cut him. White says both sides don't want to work with each other any more. Why prolong the agony?

Not all (business) relationships are built to last. Tear this one down.

--

Follow Cagewriter on Facebook and Twitter.

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Study says wind turbines raise surrounding area temperature, but only at night

Who said the butterfly effect couldn't apply to renewable energy? Though wind farms are considered pretty green on the energy-generating spectrum, it looks like they, too, have an impact on the planet. According to a study published today in the journal Nature Climate Change, turbines can raise the local temperature -- albeit slightly. From 2003 to 2011, researchers monitored satellite data for west-central Texas, which is home to 2,350-plus turbines and four of the world's largest wind farms. In that decade, scientists observed a temperature increase of 0.72 degrees in wind farm regions compared to areas without turbines. That warming trend was especially marked at night, when the temperature difference between the ground and the air is highest. The temperature increase was also higher in winter; researchers say that these cooler, windier conditions cause turbines to generate more electricity and therefore create more heat. Since the study didn't find any change in daytime temperatures, it looks like we don't have to ring the global warming alarm just yet.

Study says wind turbines raise surrounding area temperature, but only at night originally appeared on Engadget on Mon, 30 Apr 2012 14:47:00 EDT. Please see our terms for use of feeds.

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Teri Hatcher: 'Desperate Housewives' End Finally Here

Teri Hatcher is finally coming to terms with the fact that the series finale of Desperate Housewives is finally airing this May 13.

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