Monday, March 18, 2013

Vet who saved many in Iraq couldn't escape demons

He had a knack for soothing soldiers who'd just seen their buddies killed by bombs. He knew how to comfort medics sickened by the smell of blood and troops haunted by the screams of horribly burned Iraqi children.

Capt. Peter Linnerooth was an Army psychologist. He counseled soldiers during some of the fiercest fighting in Iraq. Hundreds upon hundreds sought his help. For nightmares and insomnia. For shock and grief. And for reaching that point where they just wanted to end it all.

Linnerooth did such a good job his Army comrades dubbed him The Wizard. His "magic" was deceptively simple: an instant rapport with soldiers, an empathetic manner, a big heart.

For a year during one of the bloodiest stretches of the Iraq war, Linnerooth met with soldiers 60 to 70 hours a week. Sometimes he'd hop on helicopters or join convoys, risking mortars and roadside bombs. Often, though, the soldiers came to his shoebox-sized "office" at Camp Liberty in Baghdad.

There they'd encounter a raspy-voiced, broad-shouldered guy who blasted Motorhead, Iron Maiden and other ear-shattering heavy metal, favored four-letter words and inhaled Marlboro Reds ? once even while conducting a "stop smoking" class. He was THAT persuasive.

Linnerooth knew when to be a friend and when to be a professional Army officer. He could be tough, even gruff at times, but he also was a gentle soul, a born storyteller, a proud dad who decorated his quarters with his kids' drawings and photos. He carried his newborn daughter's shoes on his ruck sack for good luck.

Linnerooth left Iraq in 2007, a few months short of the end of his 15-month tour. He couldn't take it anymore. He'd heard enough terrible stories. He'd seen enough dead and dying.

He became a college professor in Minnesota, then counseled vets in California and Nevada. He'd done much to help the troops, but in his mind, it wasn't enough. He worried about veteran suicides. He wrote about professional burnout. He grappled with PTSD, depression and anger, his despair spiraling into an overdose. He divorced and married again. He fought valiantly to get his life in order.

But he couldn't make it happen.

As the new year dawned, Pete Linnerooth, Bronze Star recipient, admired Army captain, devoted father, turned his gun on himself. He was 42.

He was, as one buddy says, the guy who could help everybody ? everybody but himself.

___

He liked to jokingly compare himself to an intrepid explorer stranded in one of the most remote corners of the earth.

Linnerooth's best buddy, Brock McNabb, recalls how they'd laugh and find parallels to the plight of Ernest Shackleton, whose ship, Endurance, became trapped in the Antarctic during an early 20th-century expedition. The crew ended up on an ice floe, scrambling to survive.

This was the 100-degree desert, of course, but for them, the analogy was apt: Both were impossible missions ? Linnerooth and two teammates were responsible for the mental stability and psychological care of thousands ? and both groups leaned on one another for emotional sustenance.

"There's no cavalry to save the day," McNabb explains. "You ARE the cavalry. There was no relief."

McNabb and a third soldier, Travis Landchild, were the tight-knit mental health crew in charge of the 2nd Brigade Combat Team, 1st Infantry Division in the Baghdad area. They were there when the surge began, rocket attacks increased and the death toll mounted.

Landchild says the three dubbed themselves "a dysfunctional tripod." Translation: One of the three "legs" was always broken, or stressed out, and without fail, "the other two would step up and support that person."

A few months into their tour, McNabb says, both he and Linnerooth ? with the approval of on-site doctors ? began taking antidepressants. "He had to have training wheels," McNabb says. "We all did."

They worked non-stop, even overnight sometimes. They listened so intently, their nightmares were not their own.

They saw guys who'd witnessed Humvees vaporize before them, medics barely out of high school dealing with double amputations, women sexually assaulted in combat zones. There were soldiers suffering from paranoia, bipolar disorder, anxiety ? one was wetting his bed. And then there were those escorted under guard after threatening suicide.

"People are in rough, rough shape ... it's misery all the time, and it does affect you," McNabb says.

Linnerooth ? the only trained psychologist of the three ? was frustrated by what he regarded as the Army's view of mental health as a second-class problem that can be minimized or overlooked during deployment, McNabb says. At times, he also felt powerless ? stabilizing soldiers, then having to return them to missions, knowing they'd be traumatized again.

"Sometimes he felt he was putting a Band-Aid over a bullet hole," McNabb says. "It would be, 'I got you to where you can sleep through the night ... but guess what? You have seven months left in your deployment.'"

For about half his tour, Linnerooth's office was a 12-by-12 trailer. His heavy-metal soundtrack ? he banned the Beatles and Pink Floyd, deeming them too sad ? provided a sound buffer. A thermal blanket serving as a makeshift room divider also provided a modicum of privacy.

Linnerooth brought hope to those gripped by hopelessness. In a desert, he could always find the glass half full.

He turned tragedies into cathartic moments: When a platoon lost a member, he'd encourage the survivors to deal with their grief by writing letters to the children of the fallen soldier, recounting the great things about their father.

He used irreverence as a balm: When he met with troops in a chapel after a suicide bomb intended for them instead struck a group of Iraqi schoolgirls, he punctuated his remarks with a four-letter word. God, he insisted, surely wouldn't mind him cussing in a religious sanctuary, all things considered. Then he offered comfort.

"It IS horrible," McNabb quotes him as saying. "'There are bad guys out there ... 'You're brave soldiers. You're being asked to do a job no one could do.'"

But Linnerooth wasn't just dealing with emotional trauma. He was in the same complex as the busy Riva Ridge Troop Medical Clinic. When mass casualties arrived, he was there squeezing IV bags, handling bandages.

Later on, talking with family, he'd hint of the horror in sketchy details, describing how a blocked drain once left the soldiers ankle-deep in blood, or the agony of Iraqi kids dying slowly.

Linnerooth did elaborate in one essay. In words both graphic and incredibly tender, he described a female soldier brought in with mortal wounds. Her Humvee, while on a rescue mission, had been struck by an armor-penetrating explosive.

"I stood at her head and considered her hair, for Christsakes!" he wrote. "The blast had mussed her hair. Removed her foot, cleaved her abdomen, but mussed her hair. For whatever reason I looked at it and longed to smooth it back from her forehead. Like I do for my children. It was reddish-blond, curly, almost kinky, and in disarray. I looked around me to see if anyone would notice this gesture, if anyone would mind. Hell, I don't know what to do in an abattoir of human suffering, it's not my job. I deal with easy things, like the paranoid, the personality disordered, and those without hope. All I wanted to do was smooth her hair, perhaps compose her for the next stage of her journey. But I never did it, and regret it to this day."

___

Even as he continued to comfort others, Linnerooth was showing signs of strain.

Ray Nixon, then a medic at Riva Ridge, remembers anguishing over critical decisions ? assigning soldiers to what could be life-and-death missions ? and talking with Linnerooth.

"Pete would always tell me, 'You're doing the best job you can. You're well trained,'" Nixon says. "He always made me feel better. He knew exactly what to say, exactly what direction to guide you in ? but Pete was very bad at taking care of himself. Any time he was having problems or getting overwhelmed, instead of asking for help, he'd lock himself in his room and try to deal with it alone."

He had always been this way. His mother, Gayle McMullen, who adopted Pete when he was 9? weeks old, recalls a loving little boy who adored animals, talked up a storm at 18 months old and was very sensitive. He clammed up when upset. "You could see something was bothering him, but he kept a lot inside," she says.

In Iraq, Linnerooth avoided socializing. Friends, he'd say, were potential patients.

His buddies gave him space, but they noticed he wasn't bouncing back as he had before.

A year into the tour, McNabb says, Linnerooth walked in a doctor's office and said: "'I can't stand it. This is too much. How much more misery and torture are these kids going to go through?'"

The doctor, McNabb says, asked if he might hurt himself. Linnerooth replied he wasn't sure.

As he was evacuated, he told McNabb he was crushed having to abandon his teammates. They saw it otherwise.

"We didn't know if any of us were going to get out alive. You never do in war," Landchild says. "We kind of had this hope that one of us made it. Yeah, he's broken as heck and he has a lot of healing to do but he got OUT."

___

He wasn't the same. His family noticed it when they met him in Schweinfurt, Germany.

"He came home burdened," says his younger sister, Mary Linnerooth Gonzalez. "He was disappointed that he couldn't affect the wheels of change. ... I think he was defeated."

Amy, Linnerooth's wife at the time ? they'd met as teens in Rochester, Minn. ? says they had trouble resuming their lives. He didn't discuss what he'd seen while in Iraq, and didn't open up at home.

"I think it was just kind of like a wall that he put up," she says. "I asked him about that later and he said if he let that guard down, then it would be like a dam flooding and it would just all come out and he couldn't be that way."

There were some early warning signs, she says, including jokes about suicide. She dismissed it as gallows humor.

In 2008, after nearly six years in the Army, Linnerooth was a civilian again, returning to an academic world where he'd thrived.

He was the kind of student professors rave about for years, describing him as "brilliant" and "amazing."

Patrick Friman, who was in charge of Linnerooth's doctoral dissertation at the University of Nevada-Reno, remembers a day when his then-student joined him for training at an out-patient psychological clinic. A mother was struggling with her 3-year-old: The girl wouldn't sleep in her own bed, wasn't toilet trained and refused to do what her mother asked.

It soon became clear that Linnerooth, the novice, was much better at relating to the mother than the trained professor. "I marveled at how well he described the problem, the solution and the steps that need to be taken to achieve it," Friman says. "She was hanging on his every word. She couldn't wait to go home to try it."

Linnerooth recommended the mother set reasonable bed times, be affectionate when her child was behaving and make other adjustments. The plan succeeded. "He wanted to learn how to work with kids and he was just a natural at it," Friman says.

Linnerooth also had made an impression at Minnesota State University-Mankato, where he earned his master's degree. Professor Daniel Houlihan, who was his adviser, remembers an enormously gifted writer who was prescient about the war ? years before, he had warned of a high military suicide rate.

He was hired to teach psychology at the school in 2008. Still raw from Iraq, he quickly became annoyed with 19 year olds griping about tough grading standards. He'd just come from a place where 19 year olds worried about their very survival.

Linnerooth began missing meetings. He seemed paranoid, spending a lot of time in his office shredding papers, Houlihan recalls.

Jeffrey Buchanan, another professor in Mankato who'd been friends with Linnerooth and his wife since grad school, says the confident, self-assured Pete was gone. "It seemed like he was questioning every decision he was making," he says.

Things were also bad at home. Amy Linnerooth says they tried marital counseling.

Her husband seemed two people, she says. "It would be like the guy you knew ... then a little thing would set him off," she recalls. "I remember telling him 'I just want to blend in with the wallpaper. I don't want to be in your way.' It was like walking on eggshells."

In early 2009, Linnerooth's depression took a disastrous turn. He nearly died from an overdose of pills.

His buddy, McNabb, phoned.

"Jesus, man you can't even kill yourself right," he teased. Linnerooth laughed.

But he also confided: "I just hated where my life was going. Here, I'm arguing with my wife. ... I want to be normal for my kids. ... I was tired of being here.'"

Amy Linnerooth says her husband was very remorseful. "He thought that was a really stupid thing to do to the kids and us," she says. She was convinced he'd never try to harm himself again.

By late 2009, though, his marriage was failing and his job was in jeopardy.

Houlihan, his colleague, approached him. "This just isn't working well," he said. "We've got to figure out how we can salvage your career."

The professor expected Linnerooth to be defensive. Instead, he was relieved to confront the problems.

He was given an extended leave and headed west to start a new life.

____

McNabb had invited his pal to him join him at the Santa Cruz County Vet Center in California.

He arrived looking terrible, but soon shed 50 pounds and shaved his long beard. He moved in across the street from McNabb. They spent nights chatting over beers.

Linnerooth liked his new surroundings but his ongoing divorce and separation from his kids weighed on him. Still, he remained an attentive, loving father. He'd fly to Minnesota often and while in California, he'd call his children, Jack, 9, and Whitney, 6, every night. He'd read to his son; he created a cartoon series for his daughter featuring a spider they called Gigerenzer. He'd Skype with his kids, too, content just to watch them watch TV.

Linnerooth also felt his work as a veterans' readjustment counselor was helping people. He spoke at symposiums about the emotional trauma of war. With McNabb, he conducted a suicide prevention class for an Army Reserve unit, even as he himself was being treated for his own PTSD.

He became more vocal about the strains on military psychologists. Linnerooth talked about the pressures to The New York Times and Time. He told the magazine in 2010 "the Army has been criminally negligent," in not having enough mental health experts to serve combat vets, putting a bigger burden on those trying to do the job.

He joined Bret Moore, another former Army psychologist he befriended before Iraq, to produce an academic paper about professional burnout. "He wanted to write and get the word out," Moore says. "It was therapeutic for him. ... He really was putting his heart and soul into it."

For a time, Linnerooth seemed happy, telling Moore about his budding relationship with Melanie Walsh, a social worker. They'd met a decade earlier when she was an undergraduate assistant at Reno. Moore was invited to their July 2011 wedding in Lake Tahoe.

As the months wore on, though, he reported marital strains. He also was missing deadlines for their paper.

Moore says he eventually toned down Linnerooth's work to make it more academic and less emotional. "You could really see the anger," he says, noting it reflected both his attitude toward the military and his disintegrating personal life. The paper was published in 2011 in an American Psychological Association journal.

Linnerooth moved to Reno to be with his new wife. He was hired by the Department of Veterans Affairs to work with vets struggling with PTSD and substance abuse.

There was a hitch, though. He was approaching a two-year deadline to get a state license required by the VA.

McNabb urged him to take the test. Whether it was depression or another reason, he didn't. The VA let him go. (The agency said in a January statement that it was forced to terminate Linnerooth because of the lack of licensing but offered to take him back once he finished the requirements.)

"He felt betrayed," his widow says. "He deteriorated after that and he deteriorated quickly."

"It broke him yet again," his sister says. "He felt let down by the system."

Even for "a fairly resilient guy," Moore says, "there was just one letdown right after the other. He never got any breathing room."

___

At the end of last summer, Linnerooth returned home to Minnesota so he could see his children daily. He did travel back to California, though, for a joyous occasion ? the birth of his son, David.

He spoke often with his buddy, McNabb, and seemed optimistic, considering new careers outside psychology But he kept his distance, too, not telling former university colleagues he was back.

Linnerooth was busy with family during the holidays: He sent his mother a text thanking her for the kids' Christmas gifts, traveled west to see his baby and sent photos of the infant in a green monster outfit to his sister, Mary. On Jan. 1, he spent a happy day with his son, Jack, and was planning another visit with David.

The next day, though, McNabb says, a fight with his wife, alcohol and a loaded gun proved a tragic combination.

He left a note with instructions, but no explanation of why he'd taken his life.

"For the record, Pete Linnerooth did not want to die," McNabb says. "He just wanted the pain to end. Big difference."

For all those who loved and admired him, for all those who saw him at his best and worst, these past weeks have been filled with sorrow, regret and inescapable irony.

"He didn't like to burden other people," his widow says. "He liked to take care of other people. I don't know anyone who knew how to comfort people like he did. ... He was very kind. He was sincere. He was generous. He was patient. He was forgiving. It's such a tragedy. He had the skill, he genuinely cared and he could have helped so many people. And now he's gone."

___

His family and friends gathered on a bitter cold January day in Minnesota to bid farewell.

The night before, his Army pals flew in from around the country and toasted their buddy with prodigious amounts of scotch and rum. They shared favorite Pete stories and placed his urn on the table, covering it with a Motorhead T-shirt.

Later in the hotel room near Fort Snelling National Cemetery, McNabb mulled over how to leave a legacy for his friend's kids ? a memorial that would give them peace and make them proud. But he was limited to 30 characters for the message on Pete's headstone. How do you honor a life in a handful of words?

McNabb then remembered something Linnerooth had once told him: "Maybe we're all meant for just one great deed and we're done."

That gave him an idea.

The next day, on a 4-degree, cloudless morning, Capt. Peter J.N. Linnerooth was laid to rest with taps and a 21-gun salute.

McNabb presented Linnerooth's son, Jack, with his father's Bronze Star, telling him: "Don't forget your dad was so very proud of you."

After the mourners met for lunch and more reminiscences, a small group of Army friends who'd served with him in Iraq returned to the unmarked stone as the sun lowered in the winter sky.

McNabb leaned over a long arm, tapped the marble and addressed Pete:

"You owe me a ---- ton of beers when I see you next," he said with a smile.

Then he surveyed the surrounding graves, calling out to Pete those buried nearby, when they served and in what branch of military. These were now his neighbors.

"You're with all these people who'll love you for all time," he said.

It was finally time to go.

On a February day, the engraved headstone arrived. It's etched with Peter Linnerooth's name, his military service and a tribute to his great deed, summed up in this spare epitaph:

HE SAVED MANY

NOW HE'S HOME.

___

Sharon Cohen is a Chicago-based national writer. She can be reached at scohen(at)ap.org.

Source: http://news.yahoo.com/vet-saved-many-iraq-couldnt-escape-demons-190136480.html

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Sunday, March 17, 2013

Facebook Brings Down The Hammer Again: Cuts Off MessageMe's Access To Its Social Graph

messagemeMessageMe, an app that launched last week and raced up the charts to the #2 spot in social networking in the U.S., is confronting Facebook’s touchiness around access to its social graph. The app’s integration with Facebook stopped functioning earlier today (see left), the result of the company’s decision to cut MessageMe off from its “Find Friends” functionality, according to sources familiar with decision. MessageMe CEO Arjun Sethi declined to comment in this story and Facebook didn’t immediately respond to requests for comment. The move resembles Facebook’s decision last month to shut off Voxer’s access to the graph, even though Voxer connected to Facebook for well over a year. Voxer is another communications app that supports calling and voice chat. Facebook cut the app off around the same time that it launched competing functionality with free voice calling to other users. In that decision, Facebook cited Section 10 of its platform policy (which is the same one it’s using in MessageMe’s case): Reciprocity and Replicating core functionality: (a) Reciprocity: Facebook Platform enables developers to build personalized, social experiences via the Graph API and related APIs. If you use any Facebook APIs to build personalized or social experiences, you must also enable people to easily share their experiences back with people on Facebook. (b) Replicating core functionality: You may not use Facebook Platform to promote, or to export user data to, a product or service that replicates a core Facebook product or service without our permission. MessageMe apparently replicates too much of Facebook Messenger’s functionality for the company to be comfortable with it. Facebook has long been touchy about providing access to the biggest of its strategic competitors like Google and Twitter. Back in 2010, Twitter’s then-CEO Ev Williams griped about the company’s unwillingness to let Twitter users look up their Facebook friends on the service or to send Facebook updates to Twitter. In the same year, Google and Facebook had a back-and-forth over Facebook’s access to Gmail’s contact importer because the social network wouldn’t send data the other way. But it’s only in the last year that the company has really stepped up enforcement against other startups.?After cutting off Voxer last month, Facebook clarified its policy, saying that apps needed to share content back to Facebook and couldn’t replicate too much of Facebook’s core functionality.?It cited the same policy in cutting off Twitter’s Vine hours after launch and Russian search

Source: http://feedproxy.google.com/~r/Techcrunch/~3/pkNbJ0PIE6E/

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roebuck alehouse: Most popular Online Business Course auctions ...

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Source: http://internetmarketingeventwatch.com/most-popular-online-business-course-auctions-399/

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Source: http://roebuck-alehouse.blogspot.com/2013/03/most-popular-online-business-course.html

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Saturday, March 16, 2013

More alt-ac sightings (Unqualified Offerings)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/291696431?client_source=feed&format=rss

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Scientists test skeletons for Black Death bacteria

(AP) ? Scientists digging a new railway in London have uncovered 13 skeletons that will be tested to see if they died from the Black Death plague in the 14th century.

The lead archaeologist of the Crossrail project, Jay Carver, says the location of the bodies and historical records suggest that the skeletons were found in a burial ground that opened at the start of the plague. Carver says scientists will study the bones to establish cause of death, and hope to map the DNA signature of the plague bacteria.

The plague began ravaging Europe in 1347, spreading quickly and killing an estimated 30 percent to 60 percent of the European population. Some 75 million people in all are believed to have died in the four-year pandemic, including 25 million Europeans.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/b2f0ca3a594644ee9e50a8ec4ce2d6de/Article_2013-03-15-EU-Britain-Black-Death/id-e267777b668b45f9a2b12ef8e1bb1256

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ScienceDaily: Child Development News

ScienceDaily: Child Development Newshttp://www.sciencedaily.com/news/mind_brain/child_development/ Read the latest research in child development including how newborns learn to think, how sleep patterns emerge, problems with toddlers and more.en-usThu, 14 Mar 2013 15:52:56 EDTThu, 14 Mar 2013 15:52:56 EDT60ScienceDaily: Child Development Newshttp://www.sciencedaily.com/images/logosmall.gifhttp://www.sciencedaily.com/news/mind_brain/child_development/ For more science articles, visit ScienceDaily.Postpartum depression: Surprising rate of women depressed after babyhttp://www.sciencedaily.com/releases/2013/03/130314124618.htm A surprisingly high number of women have postpartum depression, reports a new, large-scale study of 10,000 women. A high rate of women had considered harming themselves. The study's screening likely saved several lives. Most postpartum women with depression are not identified or treated even though they are at a higher risk for psychiatric disorders. It's a major public health problem because a woman's mental health affects her child's physical and emotional development.Thu, 14 Mar 2013 12:46:46 EDThttp://www.sciencedaily.com/releases/2013/03/130314124618.htmNew early warning system for the brain development of babieshttp://www.sciencedaily.com/releases/2013/03/130314110249.htm Researchers have developed a non-invasive optical measurement system to monitor neonatal brain activity via cerebral metabolism and blood flow.Thu, 14 Mar 2013 11:02:02 EDThttp://www.sciencedaily.com/releases/2013/03/130314110249.htmNew research discovers the emergence of Twitter 'tribes'http://www.sciencedaily.com/releases/2013/03/130314085059.htm Linguists have found evidence of how people form into tribe-like communities on social network sites such as Twitter.Thu, 14 Mar 2013 08:50:50 EDThttp://www.sciencedaily.com/releases/2013/03/130314085059.htmNo attention-boosting drugs for healthy kids, doctors urgehttp://www.sciencedaily.com/releases/2013/03/130313182022.htm The practice of prescribing drugs to boost cognitive function, or memory and thinking abilities, in healthy children and teens is misguided, according to a new statement by the American Academy of Neurology.Wed, 13 Mar 2013 18:20:20 EDThttp://www.sciencedaily.com/releases/2013/03/130313182022.htmDrug treatment corrects autism symptoms in mouse modelhttp://www.sciencedaily.com/releases/2013/03/130313182019.htm Autism results from abnormal cell communication. Testing a new theory, researchers have used a newly discovered function of an old drug to restore cell communications in a mouse model of autism, reversing symptoms of the devastating disorder.Wed, 13 Mar 2013 18:20:20 EDThttp://www.sciencedaily.com/releases/2013/03/130313182019.htmScientists find age-related changes in how autism affects the brainhttp://www.sciencedaily.com/releases/2013/03/130313123540.htm Autism spectrum disorders affect the brain activity of children and adults differently, according to new research.Wed, 13 Mar 2013 12:35:35 EDThttp://www.sciencedaily.com/releases/2013/03/130313123540.htmPunishment can enhance performance, academics findhttp://www.sciencedaily.com/releases/2013/03/130313123313.htm The stick can work just as well as the carrot in improving our performance, a team of academics has found.Wed, 13 Mar 2013 12:33:33 EDThttp://www.sciencedaily.com/releases/2013/03/130313123313.htmNeuron loss in schizophrenia and depression could be prevented, study suggestshttp://www.sciencedaily.com/releases/2013/03/130313095533.htm Gamma-aminobutyric acid (GABA) deficits have been implicated in schizophrenia and depression. In schizophrenia, deficits have been particularly well-described for a subtype of GABA neuron, the parvalbumin fast-spiking interneurons. The activity of these neurons is critical for proper cognitive and emotional functioning. It now appears that parvalbumin neurons are particularly vulnerable to oxidative stress, a factor that may emerge commonly in development, particularly in the context of psychiatric disorders like schizophrenia or bipolar disorder, where compromised mitochondrial function plays a role.Wed, 13 Mar 2013 09:55:55 EDThttp://www.sciencedaily.com/releases/2013/03/130313095533.htmAutistic children may be at greater risk of suicide ideation and attemptshttp://www.sciencedaily.com/releases/2013/03/130312152049.htm Children with an autism spectrum disorder may be at greater risk for contemplating suicide or attempting suicide than children without autism, according to researchers.Tue, 12 Mar 2013 15:20:20 EDThttp://www.sciencedaily.com/releases/2013/03/130312152049.htm'I don't want to pick!' Preschoolers know when they aren't surehttp://www.sciencedaily.com/releases/2013/03/130312152002.htm Children as young as 3 years old know when they are not sure about a decision, and can use that uncertainty to guide decision making, according to new research.Tue, 12 Mar 2013 15:20:20 EDThttp://www.sciencedaily.com/releases/2013/03/130312152002.htmKids exposed to millions of tobacco images/messages every week on prime time UK TVhttp://www.sciencedaily.com/releases/2013/03/130311201142.htm UK children are being exposed to millions of tobacco images/messages every week on prime time television, indicates new research.Mon, 11 Mar 2013 20:11:11 EDThttp://www.sciencedaily.com/releases/2013/03/130311201142.htmChildren who avoid scary situations likelier to have anxietyhttp://www.sciencedaily.com/releases/2013/03/130311201019.htm Children who avoid situations they find scary are likely to have anxiety a study of more than 800 children ages 7 to 18 found.Mon, 11 Mar 2013 20:10:10 EDThttp://www.sciencedaily.com/releases/2013/03/130311201019.htmMom's sensitivity helps language development in children with hearing losshttp://www.sciencedaily.com/releases/2013/03/130308103414.htm Psychologists demonstrate the impact sensitive parenting has on language growth for children who receive cochlear implants.Fri, 08 Mar 2013 10:34:34 ESThttp://www.sciencedaily.com/releases/2013/03/130308103414.htmUsing human brain cells to make mice smarterhttp://www.sciencedaily.com/releases/2013/03/130307123947.htm What happens when human brain cells that surround and support neurons are implanted into the brains of newborn mice? Researchers recently found that such mice had enhanced learning and memory when compared with normal mice that hadn't received the transplanted human cells. The findings indicate that these supportive cells, called glia, play an important role in human cognition.Thu, 07 Mar 2013 12:39:39 ESThttp://www.sciencedaily.com/releases/2013/03/130307123947.htmWhen food is scarce, a smaller brain will dohttp://www.sciencedaily.com/releases/2013/03/130307123944.htm A new study explains how young brains are protected when nutrition is poor. The findings reveal a coping strategy for producing a fully functional, if smaller, brain. The discovery, which was made in larval flies, shows the brain as an incredibly adaptable organ and may have implications for understanding the developing human brain as well, the researchers say.Thu, 07 Mar 2013 12:39:39 ESThttp://www.sciencedaily.com/releases/2013/03/130307123944.htmExercise shields children from stress, research indicateshttp://www.sciencedaily.com/releases/2013/03/130307091552.htm Exercise may play a key role in helping children cope with stressful situations, according to a recent study.Thu, 07 Mar 2013 09:15:15 ESThttp://www.sciencedaily.com/releases/2013/03/130307091552.htmFlip of a single molecular switch makes an old mouse brain younghttp://www.sciencedaily.com/releases/2013/03/130306134226.htm The flip of a single molecular switch helps create the mature neuronal connections that allow the brain to bridge the gap between adolescent impressionability and adult stability. Now researchers have reversed the process, recreating a youthful brain that facilitated both learning and healing in the adult mouse.Wed, 06 Mar 2013 13:42:42 ESThttp://www.sciencedaily.com/releases/2013/03/130306134226.htmSolving the 'Cocktail Party Problem': How we can focus on one speaker in noisy crowdshttp://www.sciencedaily.com/releases/2013/03/130306134218.htm In the din of a crowded room, paying attention to just one speaker's voice can be challenging. Research demonstrates how the brain homes in on one speaker to solve this "Cocktail Party Problem." Researchers discovered that brain waves are shaped so the brain can selectively track the sound patterns from the speaker of interest while excluding competing sounds from other speakers. The findings could have important implications for helping individuals with a range of deficits.Wed, 06 Mar 2013 13:42:42 ESThttp://www.sciencedaily.com/releases/2013/03/130306134218.htmFamily intervention improves mood symptoms in children and adolescents at risk for bipolar disorderhttp://www.sciencedaily.com/releases/2013/03/130306084154.htm Psychologists have found that children and adolescents with major depression or subthreshold forms of bipolar disorder - and who had at least one first-degree relative with bipolar disorder - responded better to a 12-session family-focused treatment than to a briefer educational treatment.Wed, 06 Mar 2013 08:41:41 ESThttp://www.sciencedaily.com/releases/2013/03/130306084154.htmHelp in reading foreign languageshttp://www.sciencedaily.com/releases/2013/03/130306083935.htm Recent research into how we learn is set to help people in their efforts to read a second or foreign language (SFL) more effectively. This will be good news for those struggling to develop linguistic skills in preparation for a move abroad, or to help in understanding foreign language forms, reports, contracts and instructions.Wed, 06 Mar 2013 08:39:39 ESThttp://www.sciencedaily.com/releases/2013/03/130306083935.htmPotential target to better treat, cure anxiety disordershttp://www.sciencedaily.com/releases/2013/03/130305174627.htm Researchers have, for the first time, identified a specific group of cells in the brainstem whose activation during rapid eye movement sleep is critical for the regulation of emotional memory processing.Tue, 05 Mar 2013 17:46:46 ESThttp://www.sciencedaily.com/releases/2013/03/130305174627.htmMental picture of others can be seen using fMRI, finds new studyhttp://www.sciencedaily.com/releases/2013/03/130305091000.htm It is possible to tell who a person is thinking about by analyzing images of his or her brain. Our mental models of people produce unique patterns of brain activation, which can be detected using advanced imaging techniques according to a new study.Tue, 05 Mar 2013 09:10:10 ESThttp://www.sciencedaily.com/releases/2013/03/130305091000.htmChildren of divorced parents more likely to switch, pull away from religionshttp://www.sciencedaily.com/releases/2013/03/130305090956.htm Adults whose parents were divorced are more likely to switch religions or disassociate themselves from institutional religions altogether -- but growing up in a single-parent family does not have any effect on private religious life, including praying, according to a new study.Tue, 05 Mar 2013 09:09:09 ESThttp://www.sciencedaily.com/releases/2013/03/130305090956.htmStress hormone foreshadows postpartum depression in new mothershttp://www.sciencedaily.com/releases/2013/03/130304161623.htm Women who receive strong social support from their families during pregnancy appear to be protected from sharp increases in a particular stress hormone, making them less likely to develop postpartum depression, according to a new study.Mon, 04 Mar 2013 16:16:16 ESThttp://www.sciencedaily.com/releases/2013/03/130304161623.htmMom's placenta reflects her exposure to stress and impacts offsprings' brainshttp://www.sciencedaily.com/releases/2013/03/130304151811.htm The mammalian placenta is more than just a filter through which nutrition and oxygen are passed from a mother to her unborn child. According to a new study, if a mother is exposed to stress during pregnancy, her placenta translates that experience to her fetus by altering levels of a protein that affects the developing brains of male and female offspring differently.Mon, 04 Mar 2013 15:18:18 ESThttp://www.sciencedaily.com/releases/2013/03/130304151811.htmIs baby still breathing? Is mom's obsession normal?http://www.sciencedaily.com/releases/2013/03/130304151807.htm A new mother may constantly worry and check to see if her baby is breathing. Or she may obsess about germs. A new study found postpartum moms have a much higher rate of obsessive-compulsive symptoms than the general population. This is the first large-scale study of obsessive-compulsive symptoms in new moms. The symptoms could result from hormonal changes or be adaptive, but may indicate a psychological disorder if they interfere with a mother's functioning.Mon, 04 Mar 2013 15:18:18 ESThttp://www.sciencedaily.com/releases/2013/03/130304151807.htmSpeech emerges in children on the autism spectrum with severe language delay at greater rate than previously thoughthttp://www.sciencedaily.com/releases/2013/03/130304104912.htm Study could reveals key predictors of speech gains. New findings reveal that 70 percent of children with autism spectrum disorders (ASD) who have a history of severe language delay, achieved phrase or fluent speech by age eight.Mon, 04 Mar 2013 10:49:49 ESThttp://www.sciencedaily.com/releases/2013/03/130304104912.htmADHD takes a toll well into adulthoodhttp://www.sciencedaily.com/releases/2013/03/130304104758.htm The first large, population-based study to follow children with attention-deficit hyperactivity disorder into adulthood shows that ADHD often doesn?t go away and that children with ADHD are more likely to have other psychiatric disorders as adults. They also appear more likely to commit suicide and to be incarcerated as adults.Mon, 04 Mar 2013 10:47:47 ESThttp://www.sciencedaily.com/releases/2013/03/130304104758.htmInfection during pregnancy and stress in puberty play key role in development of schizophreniahttp://www.sciencedaily.com/releases/2013/03/130301122512.htm The interplay between an infection during pregnancy and stress in puberty plays a key role in the development of schizophrenia, as behaviorists demonstrate in a mouse model. However, there is no need to panic.Fri, 01 Mar 2013 12:25:25 ESThttp://www.sciencedaily.com/releases/2013/03/130301122512.htmBritish children more exposed to alcohol promotion than adults, experts warnhttp://www.sciencedaily.com/releases/2013/02/130228194651.htm Children in Britain are more exposed to alcohol promotion than adults and need much stronger protection, warn experts.Thu, 28 Feb 2013 19:46:46 ESThttp://www.sciencedaily.com/releases/2013/02/130228194651.htmAction video games boost reading skills, study of children with dyslexia suggestshttp://www.sciencedaily.com/releases/2013/02/130228124132.htm Much to the chagrin of parents who think their kids should spend less time playing video games and more time studying, time spent playing action video games can actually make dyslexic children read better, new research suggests. In fact, 12 hours of video game play did more for reading skills than is normally achieved with a year of spontaneous reading development or demanding traditional reading treatments.Thu, 28 Feb 2013 12:41:41 ESThttp://www.sciencedaily.com/releases/2013/02/130228124132.htmCloser personal relationships could help teens overcome learning disabilitieshttp://www.sciencedaily.com/releases/2013/02/130228113449.htm A new study from Israel says that children with learning disabilities develop less secure attachments with mothers and teachers, and that closer and more secure relationships with parents and adults may help them overcome these disabilities.Thu, 28 Feb 2013 11:34:34 ESThttp://www.sciencedaily.com/releases/2013/02/130228113449.htmEating junk food while pregnant may make your child a junk food addicthttp://www.sciencedaily.com/releases/2013/02/130228103443.htm A healthy diet during pregnancy is critical to the future health of your children. New research suggests that pregnant mothers who consume junk food cause developmental changes of the opioid signaling pathway in the brains of their unborn children. Consequently, these children are less sensitive to opioids released upon consumption of foods high in fat and sugar, and need to eat more to achieve a "feel good" response.Thu, 28 Feb 2013 10:34:34 ESThttp://www.sciencedaily.com/releases/2013/02/130228103443.htmChildren with autism show increased positive social behaviors when animals are presenthttp://www.sciencedaily.com/releases/2013/02/130227183504.htm The presence of an animal can significantly increase positive social behaviors in children with autism spectrum disorders, according to new research.Wed, 27 Feb 2013 18:35:35 ESThttp://www.sciencedaily.com/releases/2013/02/130227183504.htmHomeric epics were written in 762 BCE, give or take, new study suggestshttp://www.sciencedaily.com/releases/2013/02/130227183320.htm One of literature's oldest mysteries is a step closer to being solved. A new study dates Homer's The Iliad to 762 BCE and adds a quantitative means of testing ideas about history by analyzing the evolution of language.Wed, 27 Feb 2013 18:33:33 ESThttp://www.sciencedaily.com/releases/2013/02/130227183320.htmPraising children for their personal qualities may backfirehttp://www.sciencedaily.com/releases/2013/02/130227183316.htm Praising children, especially those with low self-esteem, for their personal qualities rather than their efforts may make them feel more ashamed when they fail, according to new research.Wed, 27 Feb 2013 18:33:33 ESThttp://www.sciencedaily.com/releases/2013/02/130227183316.htmFirst grade math skills set foundation for later math abilityhttp://www.sciencedaily.com/releases/2013/02/130227151302.htm Children who failed to acquire a basic math skill in first grade scored far behind their peers by seventh grade on a test of the mathematical abilities needed to function in adult life, according to researchers.Wed, 27 Feb 2013 15:13:13 ESThttp://www.sciencedaily.com/releases/2013/02/130227151302.htmResearch explores factors that impact adolescent mental healthhttp://www.sciencedaily.com/releases/2013/02/130227151258.htm Research indicates that half of all lifetime cases of mental illness begin by age 14, well before adulthood. Three new studies investigate the cognitive, genetic and environmental factors that may contribute to mental health disorders in adolescence.Wed, 27 Feb 2013 15:12:12 ESThttp://www.sciencedaily.com/releases/2013/02/130227151258.htmAuthors: Develop digital games to improve brain function and well-beinghttp://www.sciencedaily.com/releases/2013/02/130227134338.htm Neuroscientists should help to develop compelling digital games that boost brain function and improve well-being, say two professors specializing in the field.Wed, 27 Feb 2013 13:43:43 ESThttp://www.sciencedaily.com/releases/2013/02/130227134338.htmStudy connects early childhood with pain, depression in adulthoodhttp://www.sciencedaily.com/releases/2013/02/130227121910.htm New research examines how childhood socioeconomic disadvantages and maternal depression increase the risk of major depression and chronic pain when they become adults.Wed, 27 Feb 2013 12:19:19 ESThttp://www.sciencedaily.com/releases/2013/02/130227121910.htmNew studies link gene to selfish behavior in kids, find other children natural givershttp://www.sciencedaily.com/releases/2013/02/130227102940.htm Most parents would agree that raising a generous child is an admirable goal -- but how, exactly, is that accomplished? New results shed light on how generosity and related behaviors -- such as kindness, caring and empathy -- develop, or don't develop, in children from 2 years old through adolescence.Wed, 27 Feb 2013 10:29:29 ESThttp://www.sciencedaily.com/releases/2013/02/130227102940.htm'Network' analysis of brain may explain features of autismhttp://www.sciencedaily.com/releases/2013/02/130227102022.htm A look at how the brain processes information finds distinct pattern in autistic children. Using EEGs to track the brain's electrical cross-talk, researchers found structural difference in brain connections. Compared with neurotypical children, those with autism have multiple redundant connections between neighboring brain areas at expense of long-distance links. The study, using "network analysis" like with airlines or electrical grids, may help in understanding some classic autistic behaviors.Wed, 27 Feb 2013 10:20:20 ESThttp://www.sciencedaily.com/releases/2013/02/130227102022.htmIncreased risk of sleep disorder narcolepsy in children who received swine flu vaccinehttp://www.sciencedaily.com/releases/2013/02/130226194006.htm A study finds an increased risk of narcolepsy in children and adolescents who received the A/H1N1 2009 influenza vaccine (Pandemrix) during the pandemic in England.Tue, 26 Feb 2013 19:40:40 ESThttp://www.sciencedaily.com/releases/2013/02/130226194006.htmSleep reinforces learning: Children?s brains transform subconsciously learned material into active knowledgehttp://www.sciencedaily.com/releases/2013/02/130226081155.htm During sleep, our brains store what we have learned during the day a process even more effective in children than in adults, new research shows.Tue, 26 Feb 2013 08:11:11 ESThttp://www.sciencedaily.com/releases/2013/02/130226081155.htmHigher levels of several toxic metals found in children with autismhttp://www.sciencedaily.com/releases/2013/02/130225162231.htm Researchers have found significantly higher levels of toxic metals in children with autism, compared to typical children. They hypothesize that reducing early exposure to toxic metals may help lessen symptoms of autism, though they say this hypotheses needs further examination.Mon, 25 Feb 2013 16:22:22 ESThttp://www.sciencedaily.com/releases/2013/02/130225162231.htmDoing good is good for you: Volunteer adolescents enjoy healthier heartshttp://www.sciencedaily.com/releases/2013/02/130225162229.htm Giving back through volunteering is good for your heart, even at a young age, according to researchers.Mon, 25 Feb 2013 16:22:22 ESThttp://www.sciencedaily.com/releases/2013/02/130225162229.htmGiving a voice to kids with Down syndromehttp://www.sciencedaily.com/releases/2013/02/130225122039.htm A new case study shows children with Down syndrome can benefit from conventional stuttering treatment.Mon, 25 Feb 2013 12:20:20 ESThttp://www.sciencedaily.com/releases/2013/02/130225122039.htmUltrasound reveals autism risk at birth, study findshttp://www.sciencedaily.com/releases/2013/02/130225112510.htm Low-birth-weight babies with a particular brain abnormality are at greater risk for autism, according to a new study that could provide doctors a signpost for early detection of the still poorly understood disorder.Mon, 25 Feb 2013 11:25:25 ESThttp://www.sciencedaily.com/releases/2013/02/130225112510.htmParents talking about their own drug use to children could be detrimentalhttp://www.sciencedaily.com/releases/2013/02/130222083127.htm Parents know that one day they will have to talk to their children about drug use. The hardest part is to decide whether or not talking about ones own drug use will be useful in communicating an antidrug message. Recent research found that children whose parents did not disclose drug use, but delivered a strong antidrug message, were more likely to exhibit antidrug attitudes.Fri, 22 Feb 2013 08:31:31 ESThttp://www.sciencedaily.com/releases/2013/02/130222083127.htmScientists make older adults less forgetful in memory testshttp://www.sciencedaily.com/releases/2013/02/130221143946.htm Scientists have found compelling evidence that older adults can eliminate forgetfulness and perform as well as younger adults on memory tests. The cognitive boost comes from a surprising source -- a distraction learning strategy.Thu, 21 Feb 2013 14:39:39 ESThttp://www.sciencedaily.com/releases/2013/02/130221143946.htmHow human language could have evolved from birdsong: Researchers propose new theory on deep roots of human speechhttp://www.sciencedaily.com/releases/2013/02/130221141608.htm The sounds uttered by birds offer in several respects the nearest analogy to language," Charles Darwin wrote in "The Descent of Man" (1871), while contemplating how humans learned to speak. Language, he speculated, might have had its origins in singing, which "might have given rise to words expressive of various complex emotions." Linguistics and biology now researchers propose a new theory on the deep roots of human speech.Thu, 21 Feb 2013 14:16:16 ESThttp://www.sciencedaily.com/releases/2013/02/130221141608.htmEarly life stress may take early toll on heart functionhttp://www.sciencedaily.com/releases/2013/02/130221104330.htm Early life stress like that experienced by ill newborns appears to take an early toll of the heart, affecting its ability to relax and refill with oxygen-rich blood, researchers report.Thu, 21 Feb 2013 10:43:43 ESThttp://www.sciencedaily.com/releases/2013/02/130221104330.htmSignaling pathway linked to fetal alcohol risk: Molecular switch promises new targets for diagnosis and therapyhttp://www.sciencedaily.com/releases/2013/02/130220170736.htm Scientists have identified a molecular signaling pathway that plays an important role in the development of fetal alcohol spectrum disorder.Wed, 20 Feb 2013 17:07:07 ESThttp://www.sciencedaily.com/releases/2013/02/130220170736.htmBullied children can suffer lasting psychological harm as adultshttp://www.sciencedaily.com/releases/2013/02/130220163629.htm Bullied children grow into adults who are at increased risk of developing anxiety disorders, depression and suicidal thoughts, according to a new study.Wed, 20 Feb 2013 16:36:36 ESThttp://www.sciencedaily.com/releases/2013/02/130220163629.htmChildren with brain lesions able to use gestures important to language learninghttp://www.sciencedaily.com/releases/2013/02/130220123413.htm Children with brain lesions suffered before or around the time of birth are able to use gestures -- an important aspect of the language learning process -- to convey simple sentences.Wed, 20 Feb 2013 12:34:34 ESThttp://www.sciencedaily.com/releases/2013/02/130220123413.htmAdding movement to 'dry run' mental imagery enhances performancehttp://www.sciencedaily.com/releases/2013/02/130219201523.htm Adding movement to mental rehearsal can improve performance finds a new study. For high jumpers the study shows that dynamic imagery improves the number of successful attempts and the technical performance of jumps The technique of mental rehearsal is used to consolidate performance in many disciplines including music and sport. Motor imagery and physical practice use overlapping neural networks in the brain and the two together can improve performance as well as promoting recovery from injury.Tue, 19 Feb 2013 20:15:15 ESThttp://www.sciencedaily.com/releases/2013/02/130219201523.htmBiological marker of dyslexia discovered: Ability to consistently encode sound undergirds the reading processhttp://www.sciencedaily.com/releases/2013/02/130219172159.htm Researchers believe they have discovered a biological marker of dyslexia, a disorder affecting up to one out of 10 children that makes learning to read difficult. The researchers found a systematic relationship between reading ability and the consistency with which the brain encodes sounds. The good news: Response consistency can be improved with auditory training.Tue, 19 Feb 2013 17:21:21 ESThttp://www.sciencedaily.com/releases/2013/02/130219172159.htmLanguage protein differs in males, femaleshttp://www.sciencedaily.com/releases/2013/02/130219172153.htm Male rat pups have more of a specific brain protein associated with language development than females, according to a new study. The study also found sex differences in the brain protein in a small group of children. The findings may shed light on sex differences in communication in animals and language acquisition in people.Tue, 19 Feb 2013 17:21:21 ESThttp://www.sciencedaily.com/releases/2013/02/130219172153.htmInfants in poverty show different physiological vulnerabilities to the care-giving environmenthttp://www.sciencedaily.com/releases/2013/02/130219141016.htm Some infants raised in poverty exhibit physical traits that make them more vulnerable to poor care-giving, according to new research. The combination of physiological vulnerability and poor care-giving may lead these children to show increased problem behaviors later in childhood.Tue, 19 Feb 2013 14:10:10 ESThttp://www.sciencedaily.com/releases/2013/02/130219141016.htmMusic therapy improves behavior in children with autism, study suggestshttp://www.sciencedaily.com/releases/2013/02/130219140100.htm Weekly music therapy sessions can have a positive effect on behavior in children with autism, reports a new article. In a study of 41 children, improvements were seen particularly in inattentive behaviors over a ten month period.Tue, 19 Feb 2013 14:01:01 ESThttp://www.sciencedaily.com/releases/2013/02/130219140100.htm

Source: http://www.sciencedaily.com/rss/mind_brain/child_development.xml

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Saturday, March 2, 2013

Metal ions regulate terpenoid metabolism in insects

Friday, March 1, 2013

Max Planck scientists in Jena, Germany, have discovered an unusual regulation of enzymes that catalyze chain elongation in an important secondary metabolism, the terpenoid pathway. In the horseradish leaf beetle Phaedon cochleariae a single enzyme can trigger the production of two completely different substances depending on whether it is regulated by cobalt, manganese or magnesium ions: iridoids, which are defensive substances the larvae use to repel predators, or juvenile hormones, which control insect's development. Insects unlike plants do not have a large arsenal of the proteins called isoprenyl diphosphate synthases. Therefore they may have developed another efficient option to channel metabolites into the different directions of terpenoid metabolism by using metal ions for control. (PNAS, Early Edition, February 25, 2013, DOI:10.1073/pnas.1221489110)

Natural products: 40,000 terpenes

Apart from the primary metabolism which produces substances that ensure the survival of the cells, there are additional biosynthetic pathways in all organisms. Their products may be less important for a single cell, but they can nevertheless be essential for the whole organism. These pathways are summarized as secondary metabolism. One of them is the terpenoid pathway: with more than 40,000 different known structures it generates one of the largest classes of natural products. Terpenoid molecules have diverse functions and can act as components in molecular signaling pathways, as toxins, fragrances or hormones.

The basic unit of all terpenes is a simple molecule containing five carbon atoms that can be joined to chains of different length. There are monoterpenes (C10 units, 2 x C5), sesquiterpenes (C15, 3 x C5), and even polymers, such as natural rubber, which comprises several hundred C5 units. Special enzymes mediate chain elongation. These enzymes have attracted the curiosity of scientists at the Max Planck Institute for Chemical Ecology, Jena, and the Leibniz Institute for Plant Biochemistry in Halle. They studied mechanistic alternatives of how chain elongation is regulated.

Metal ions instead of specialized enzymes

Enzymes involved in chain elongation belong to the group of isoprenyl diphosphate synthases. Such an enzyme was isolated from larvae of the horseradish leaf beetle Phaedon cochleariae. It raised the interest of Antje Burse, project group leader in the Department of Bioorganic Chemistry at the Max Planck Institute for Chemical Ecology.

Experiments with larvae in which the enzyme encoding gene was silenced showed that the protein was involved in the formation of the C10 monoterpene chrysomelidial that larvae produce to defend themselves against predators. The larvae accumulate this monoterpene in special glands and release it as a defensive secretion when they are attacked by their enemies, such as ants.

However, surprising results emerged after comprehensive biochemical characterization of the enzyme. "After we had conducted an in vitro analysis of the protein, including measurements of product formation in the presence of different metal ions as co-factors, we were surprised to discover that only geranyl diphosphate (C10), a precursor for the defensive substance chrysomelidial, was produced after addition of cobalt and manganese ions. On the other hand, adding magnesium ions resulted in the formation of farnesyl diphosphate (C15), a potential precursor for juvenile hormones, which is 5 carbon atoms longer," says the scientist. All three metals were found in larval tissue, leading to the assumption that enzyme catalysis is directed by the different metal co-factors in the larvae, whichever is predominant in amount: Towards toxin or hormone ? physiologically a major difference.

Sequence comparisons cannot replace a thorough biochemical analysis

How the different metal ions modify the product range of the enzyme is still unclear. It is very likely that the varying atomic radii of the metal ions involved in the catalysis effect changes in the spatial structure of the enzyme, which prevent or allow the admission of a third C5 unit and hence result in the production of C10 or C15 molecules.

"Our experiments provide two important findings," says Wilhelm Boland, director at the Max Planck Institute. "First, the directing influence of metal ions on the product formation of isoprenyl diphosphate synthases is a novel "control element" in the regulation of the terpene metabolism which should be included in future experimental settings. And secondly: The diversity of terpenoid molecules cannot be attributed solely to the broad substrate specificity of some enzymes in the last steps of the metabolic pathway, but is in fact already inherent in early biosynthetic steps." Nature continues to provide interesting answers to the question how organisms manage to produce tens of thousands of different secondary metabolites. [JWK/AO]

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Sindy Frick, Raimund Nagel, Axel Schmidt, Ren R. Bodemann, Peter Rahfeld, Gerhard Pauls, Wolfgang Brandt Jonathan Gershenzon, Wilhelm Boland, Antje Burse: Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway. Proceedings of the National Academy of Sciences USA, Early Edition, February 25, 2013, DOI:10.1073/pnas.1221489110 http://dx.doi.org/10.1073/pnas.1221489110

Max Planck Institute for Chemical Ecology: http://www.ice.mpg.de

Thanks to Max Planck Institute for Chemical Ecology for this article.

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Source: http://www.labspaces.net/127068/Metal_ions_regulate_terpenoid_metabolism_in_insects

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